Allostasis and Drug Addiction

The term addiction and the medical language is a mental disorder is manifested by the desire unusual dependence and compulsive indulgence of some activities such as drug addiction, alcoholism, gambling, video games, crime, money, work, eat too much, or pornography tobacco addiction. The fact is that it is no end to the list, but because these substances or activities always involves a negative impact on individual and social life are purpose. compulsive addiction also described as being possessed, and create excessive psychological dependence in drug addicts on their individual preferences.

However, addiction is the term often used psychological dependence and usually means problems accompanying drug or drug abuse. But it is also the same used for problems such as compulsive overeating or when the medical community does not recognize them as problems of addiction. There are> Addiction, which is not related substance such as gambling and computer addiction in such cases dependence ago. A recurring compulsion felt by individuals to carry on business in some details do not take account of the harmful consequences.

Various forms of addiction
In the U.S. the term "addiction" is not used) in the Diagnostic and Statistical Manual (DSM-IV TR is that of "addiction"for physical dependence, abuse, or non-existence of substances or drugs. The dependency section essentially says ".... When individual use of use of alcohol or other drugs despite problems related to substance persists, it can be diagnosed with alcohol abuse. Compulsive and repeated use can cause tolerance to the effects and results of the drug when used reduces withdrawal symptoms and stopped. This, along with drug abuse are disorders substance ........" The terminology is divided between physicians and psychiatrists, as a previous call to this problem or illness as a psychological dependence or addiction and then as a substance or physical dependence.

Now there are trends between physical dependence and withdrawal symptoms of psychological dependence "compulsive, uncontrolled use" without damage occurs characterized by another person or sustained. Clinically, it is referred to as "obsessive", but not necessarily> Drug addiction.

It 's a lesser known factor called pseudo-addiction. This happens when a patient looking for drugs, having worked with for a long time to treat. This reflects the psychological dependence or addiction, but eventually it may happen that the patient may also have been treated. Such cases are numerous, in treating patients with opioids, to relieve pain. Tends to treat as appropriate to remove that dependency. Further studies arenecessary for the effectiveness or substitute for drugs such as opiates.

Allostasis: What is it?
If a person is prone to drug addiction, drug or that he or she will enter into a new state called allostatic state deviation from normal levels of change in the normal state. Allostasis is a process to maintain stability when changing the behavior and physiological functions. Drug addiction and brain damageBody by pathological conditions caused by damage to allostatic load. The result of the allostatic load is a constant state of depression, resulting from changes in allostatic. This will force drug addicts before their brain and body to look back in the normal allostatic for a constant state of stress. It is observed that investigated the presence of acute situational stress factors inducing drug trends.

Allostasis is a new concept proposed by Sterling and Eyer in 1988. Thisis a process that creates stability in an emergency and occurs endogenously in our system to maintain physiological balance. The word allostasis and homeostasis of the original greek words are derived, "homeopathic" means "equal" and stasis means "stable", meaning homeostasis ", which remain stable for a constant. So, with the word allostasis in greek "to" means "variable" and statistical means "stable" means allostasis "remain stable variable. Allostasis is the process of implementationStability through physiological or behavioral changes, and this may alter the HPA axis (hypothalamus-pituitary-adrenal axis), hormones, cytokines, autonomic nervous system and other systems are carried out and are generally short term.

The process of allostasis is of paramount importance, and this helps the organisms actively modify or adapt to unforeseen or unpredictable events in life. allostatic load refers to the cumulative costs that the body charged allostasis to restore stability. Allostatic overloadcan lead to severe pathophysiology. There are two types of allostatic overload proposal, which leads to the following reaction:

Type - I: This is the time to allostatic overload occurs because of growing energy demand exceeds supply and lead to the phase of life that the history of emergency. A normal fault is restored down allostatic load.

Type - II: allostatic congestion occurs when energy demand increases social conflicts orany kind of social dysfunction. In these cases, the normal secretion of glucocorticoids and other mediators of allostasis activities such as neurotransmitters of the CNS, autonomic nervous system, inflammatory cytokines wax. However, if the loads remain high allostatic then develop chronic conditions. It 'something like that, when an individual dehydrogenated to be stressed though not continue to help the body function again. This will involve the use ofindividual body. Although the human body is adaptable, but not to wear allostatic overload for a very long time without danger.

Adaptogens that can help you get curb allostatic load. Adaptogens are herbal or pharmaceutical substance, are non-toxic doses, and regularly produce non-specific defensive response to stress. Restoring normal HPA axis. Adaptogens are a new class of metabolic regulation of homeostatic and allostatic change mitigationAbout functional activity of these systems, or increase of less functional systems.

Allostasis and Drug Addiction
substance addiction or drug addiction is a chronic disease manifested the compulsive tendency to refrain from any drugs or substances and to try to manage constraints and desires of magnitude due to allostatic overload. increasing the level of revenue is hedonistic and surpasses the individual from a negative emotional state when them. Changes allostatic systems help to identify the impact of drug abuse and the causes of the neurobiological and neuro-adaptive. The reward system of the brain in drug addiction concerns some key elements of the basal forebrain macrostructure amygdala. The change in stress and reward systems of the brain seems to stability in allostatic state in contradiction to maintain the homeostatic state, this shows the development of vulnerability and the recurrence> Drug addiction. allostatic state of abstinence longer than the target profit is more to addiction treatment, drug and behavioral therapies. When it comes to recovering from drug addiction, it is important for the patient functions in the brain occur and full conscious awareness of how the component allostasis these concerns.

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